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Docetaxel-Loaded Fluorescent Liquid-Crystalline Nanoparticles for Cancer Theranostics

Meli, Valeria; Caltagirone, Claudia; Falchi, Angela M.; Hyde, Stephen T.; Lippolis, Vito; Monduzzi, Maura; Obiols-Rabasa, Marc; Rosa, Antonella; Schmidt, Judith; Talmon, Yeshayahu; Murgia, Sergio

Customer publications

Docetaxel-Loaded Fluorescent Liquid-Crystalline Nanoparticles for Cancer Theranostics

Meli, Valeria; Caltagirone, Claudia; Falchi, Angela M.; Hyde, Stephen T.; Lippolis, Vito; Monduzzi, Maura; Obiols-Rabasa, Marc; Rosa, Antonella; Schmidt, Judith; Talmon, Yeshayahu; Murgia, Sergio

Here, we describe a novel monoolein-based cubosome formulation engineered for possible theranostic applications in oncology. The Docetaxel-loaded nanoparticles were stabilized in water by a mixture of commercial Pluronic (poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer) F108 (PF108) and rhodamine- and folate-conjugated PF108 so that the nanoparticles possess…
Mesoporous tertiary oxides via a novel amphiphilic approach

Bennett, Natasha; Seddon, Annela M.; Hallett, James E.; Kockelmann, Winfried; Ting, Valeska P.; Sadasivan, Sajanikumari; Tooze, Robert P.; Hall, Simon R.

Customer publications

Mesoporous tertiary oxides via a novel amphiphilic approach

Bennett, Natasha; Seddon, Annela M.; Hallett, James E.; Kockelmann, Winfried; Ting, Valeska P.; Sadasivan, Sajanikumari; Tooze, Robert P.; Hall, Simon R.

We report a facile biomimetic sol-gel synthesis using the sponge phase formed by the lipid monoolein as a structure-directing template, resulting in high phase purity, mesoporous dysprosium- and gadolinium titanates. The stability of monoolein in a 1,4-butanediol and water mixture complements the use of a simple sol-gel metal oxide synthesis…
Monodisperse Cylindrical Micelles and Block Comicelles of Controlled Length in Aqueous Media

Nazemi, Ali; Boott, Charlotte E.; Lunn, David J.; Gwyther, Jessica; Hayward, Dominic W.; Richardson, Robert M.; Winnik, Mitchell A.; Manners, Ian

Customer publications

Monodisperse Cylindrical Micelles and Block Comicelles of Controlled Length in Aqueous Media

Nazemi, Ali; Boott, Charlotte E.; Lunn, David J.; Gwyther, Jessica; Hayward, Dominic W.; Richardson, Robert M.; Winnik, Mitchell A.; Manners, Ian

Cylindrical block copolymer micelles have shown considerable promise in various fields of biomedical research. However, unlike spherical micelles and vesicles, control over their dimensions in biologically relevant solvents has posed a key challenge that potentially limits in depth studies and their optimization for applications. Here, we report the preparation of…
Increasing time of ignition for PS-clay nanocomposites filled with [Fe(bpy)3]2+-modified hectorite

Hausner, Josef; Fischer, Bianca; Stöter, Matthias; Edenharter, Andreas; Schmid, Jasmin; Kunz, Raphael; Rosenfeldt, Sabine; Altstädt, Volker; Breu, Josef

Customer publications

Increasing time of ignition for PS-clay nanocomposites filled with [Fe(bpy)3]2+-modified hectorite

Hausner, Josef; Fischer, Bianca; Stöter, Matthias; Edenharter, Andreas; Schmid, Jasmin; Kunz, Raphael; Rosenfeldt, Sabine; Altstädt, Volker; Breu, Josef

While previously reported polystyrene(PS)-clay nanocomposites all show a reduced time of ignition (tig) compared to the neat polymer, we observe a significant longer tig for a clay filler that has been modified with a highly temperature stable inorganic complex cation, trisbipyridine-iron(II) (2+). We compare cone data of nanocomposites filled with…
Supramolecular Nanocomposites: Dual-Functional Cholesteric Hydroxypropyl Cellulose Esters Chemically Linked to Gold Nanoparticles

Ohlendorf, Peter; Dulle, Martin; Förster, Stephan; Greiner, Andreas

Customer publications

Supramolecular Nanocomposites: Dual-Functional Cholesteric Hydroxypropyl Cellulose Esters Chemically Linked to Gold Nanoparticles

Ohlendorf, Peter; Dulle, Martin; Förster, Stephan; Greiner, Andreas

Functionalization of metal nanoparticles with liquid crystal polymers (LCP) is attractive for the formation of supramolecular structures with unique physical properties. We discovered that the chemical linkage of a liquid crystalline thiolated cellulose ester (HPC-MTP_80) to gold nanoparticles (AuNP) leads, by control of the supramolecular structure, to a novel concept…