Self-assembly – How SAXS/WAXS helps investigate nanoribbons formed with aramid amphiphiles for more stability
Hierarchical self-assembly of small molecules is a tried and tested method to obtain nanostructured materials. The intrinsic dynamics and (bio)degradability of these materials ...
Number concentrations for Gold Nanoparticles: robust and traceable measurements in the lab
SAXS laboratory instruments provide traceable number concentration measurements for nanoparticles. Nanoparticles (NPs) are an essential building block for ...
Join DTI Webinar: why you should use X-rays in formulation of biologics
On December 10, 2020, 15.00-16.00 (CET), the Danish Technological Institute together with BioPeople will host a webinar with renowned Xenocs customers titled “Why you should use X-rays in formulation of biologics”
Size distribution of nanoparticles: powders, dispersions and composites
Size distributions of industrial nanoparticles have been determined in various forms for quality assessment and process monitoring. Nanoparticles are being produced at an increasing rate and have become an essential building block for the development of new materials with improved properties. The performance of the final products depends not only…
Vesicles
Probing the effect of oxidation on model lipid bilayers The vital function of cells depends strongly on cell membranes which enclose cellular compartments and separate the cell interior from the extracellular domain. Oxidative stress for example damages the cell membrane and is at the origin of many pathological conditions such…
Microgels
Screening of stimuli-responsive colloidal particles Microgels are colloidal particles consisting of cross-linked 3-dimensional polymer networks. These particles have the ability to shrink or swell substantially in response to external stimuli such as temperature, pH, ionic strength and light, allowing triggered release of encapsulated bioactive molecules. They additionally protect these loaded…
Thorough investigation of oligomers during protein fibrillation
The transient nature of aggregates during the fibrillation process of α-synuclein is highlighted with in-house SAXS experiments using the BioXolver. Protein aggregation into fibrillar structures is associated with a variety of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s diseases. It is becoming increasingly evident that the toxic species causing the…
In-lab SEC-SAXS for structural investigation of complex samples
How to study the structure of complex biological samples? High quality data and 3D envelopes can be obtained on small and large proteins with SEC-SAXS in the lab Small-angle X-ray scattering (SAXS) is commonly used to investigate the solution structure of biological macromolecules. Highly accurate results can be obtained with…
Protein-protein interactions – from in vivo functionality to pharmaceutics and food science
Salt concentration and pH impact were studied on lysozyme and BSA systems respectively by investigating various parameters (osmotic second virial coefficient, folding state and 3D shape). Protein-protein interactions are relevant for various biological processes, such as transcription and signal transduction, but also for protein crystallization, stability and shelf-life of pharmaceutical…
Arkema and the Nano-inXider
As a designer of materials and innovative solutions, Arkema shapes materials and creates new uses that accelerate customer performance in lightweight and design materials, biosourced materials, new energies, water management, solutions for electronics, and the performance and home insulation. For the development of new polymers, Arkema used to characterize materials…