la Rica, Robertoáde; ThomasáPashuck, E.; others
A designer peptide as a template for growing Au nanoclusters
A peptide was designed to generate a sub-nanometric template that guides the growth of fluorescent gold nanoclusters. The peptide was endorsed with nucleating moieties and a three-dimensional structure that arrests the growth of ultrasmall nanoparticles. The nanoclusters are not cytotoxic and can be found in the cytosol of…
On the self-assembly of a tryptophan labeled deoxycholic acid
Travaglini, Leana; Gubitosi, Marta; Gregorio, Maria Chiara di; Pavel, Nicolae Viorel; D’Annibale, Andrea; Giustini, Mauro; Tellini, Victor Hugo Soto; Tato, José Vázquez; Obiols-Rabasa, Marc; Bayati, Solmaz; Galantini, Luciano
Self-assembly of peptides and bile acids has been widely investigated because of their biological role and their potential as a tool for the preparation of nanostructured biomaterials. We herein report both the synthesis and the self-association behavior of a compound that combines the aggregation properties of bile acid- and amino…
The Effect of Protein PEGylation on Physical Stability in Liquid Formulation
Holm, Louise Stenstrup; Mcumber, Aaron; Rasmussen, Jakob Ewald; Obiols-Rabasa, Marc; Thulstrup, Peter W.; Kasimova, Marina R.; Randolph, Theodore W.; van de Weert, Marco
The presence of micron aggregates in protein formulations has recently attracted increased interest from regulatory authorities, industry, and academia because of the potential undesired side effects of their presence. In this study, we characterized the micron aggregate formation of hen egg-white lysozyme (Lyz) and its diPEGylated (5 kDa) analog as…
Sugar–Bile Acid-Based Bolaamphiphiles: From Scrolls to Monodisperse Single-Walled Tubules
Gubitosi, Marta; Travaglini, Leana; D’Annibale, Andrea; Pavel, Nicolae V.; Vázquez Tato, José; Obiols-Rabasa, Marc; Sennato, Simona; Olsson, Ulf; Schillén, Karin; Galantini, Luciano
The introduction of a mannose residue on carbon 3 of lithocholic acid gives rise to an asymmetric and rigid bolaamphiphilic molecule, which self-assembles in water to form elongated tubular aggregates with an outer diameter of about 20 nm. These tubular structures display a temporal evolution, where the average tube diameter…
Interactions of Small Dendrimers with Sodium Dodecyl Sulfate at the Air–Water Interface
Yanez Arteta, Marianna; Campbell, Richard A.; Watkins, Erik B.; Obiols-Rabasa, Marc; Schillén, Karin; Nylander, Tommy
We have determined how the bulk behavior of mixtures of small cationic poly(amidoamine) dendrimers (generation 2, PAMAM-G2) and sodium dodecyl sulfate (SDS) affects the structure and composition of the adsorbed layers at the air?water interface. The aim is to reveal how the size of a well-defined hyperbranched polyelectrolyte affects the…
Water-Insoluble Surface Coatings of Polyion–Surfactant Ion Complex Salts Respond to Additives in a Surrounding Aqueous Solution
Gustavsson, Charlotte; Obiols-Rabasa, Marc; Piculell, Lennart
Hydrated, but water-insoluble, ?complex salts? (CS) composed of alkyltrimethylammonium surfactant ions with polyacrylate counterions are known to exhibit a rich phase behavior in bulk mixtures with water and have recently been shown to act as water-responsive surface coatings. Here it is shown, by SAXS measurements, that surface coatings of CS…
Tailoring Supramolecular Nanotubes by Bile Salt Based Surfactant Mixtures
Gubitosi, Marta; Travaglini, Leana; di Gregorio, Maria Chiara; Pavel, Nicolae V.; Vázquez Tato, José; Sennato, Simona; Olsson, Ulf; Schillén, Karin; Galantini, Luciano
An approach for tailoring self-assembled tubular structures is described. By controlling the relative composition of a two-component surfactant mixture comprising the natural bile salt lithocholate and its bolamphiphilic derivative, it was possible to finely tune the nanotube cross-section of the mixed tubular aggregates that self-associated spontaneously in aqueous solution at…
Thermo-Resistant Soft Glassy Suspensions of Polymeric Micellar Nanoparticles in Ionic Liquid
Gkermpoura, Sandra; Obiols-Rabasa, Marc; Iatridi, Zacharoula; Tsitsilianis, Constantinos
ACS Applied Materials & Interfaces, 2015, vol 7, 23, pp. 12411-12421DOI:10.1021/am507587sVisit the full articleBack to the overview
Multi stimuli response of a single surfactant presenting a rich self-assembly behavior
Gregorio, M. C. di; Varenik, M.; Gubitosi, M.; Travaglini, L.; Pavel, N. V.; Jover, A.; Meijide, F.; Regev, O.; Galantini, L.
This work reports on the multi stimuli sensitivity of a cholic acid derivative in a buffer. The molecules self-organize in single walled tubules at room temperature and pH 8.0–9.5. By increasing the pH to 10.0–12.0, these tubules open up and form scrolls, which transform by aging into different tubular structures.…
Lithium-Salt-Containing High-Molecular-Weight Polystyrene-block-Polyethylene Oxide Block Copolymer Films
Metwalli, Ezzeldin; Rasool, Majid; Brunner, Simon; Müller-Buschbaum, Peter
Ionic conductivity in relation to the morphology of lithium-doped high-molecular-weight polystyrene-block-polyethylene oxide (PS-b-PEO) diblock copolymer films was investigated as solid-state membranes for lithium-ion batteries. The tendency of the polyethylene (PEO) block to crystallize was highly suppressed by increasing both the salt-doping level and the temperature. The PEO crystallites…