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Theranostic hexosomes for cancer treatments: an in vitro study

Meli, Valeri; Caltagirone, Claudia; Sinico, Chiara; Lai, Francesco; Falchi, Angela M.; Monduzzi, Maura; Obiols-Rabasa, Marc; Picci, Giacomo; Rosa, Antonella; Schmidt, Judith; Talmon, Yeshayahu; Murgia, Sergio

 Customer publications

Theranostic hexosomes for cancer treatments: an in vitro study

Meli, Valeri; Caltagirone, Claudia; Sinico, Chiara; Lai, Francesco; Falchi, Angela M.; Monduzzi, Maura; Obiols-Rabasa, Marc; Picci, Giacomo; Rosa, Antonella; Schmidt, Judith; Talmon, Yeshayahu; Murgia, Sergio

We have formulated and investigated innovative lipid-based nanoparticles characterized by a reverse hexagonal liquid crystalline inner structure (hexosomes). These nanoparticles were doped with a potent, highly water insoluble anticancer drug, namely docetaxel, and stabilized by a mixture of commercial and folate- and rhodamine-conjugated Pluronic F108. Thus, they simultaneously possess…
Cubosomes for in vivo fluorescence lifetime imaging

Biffi, Stefania; Andolfi, Laura; Caltagirone, Claudia; Garrovo, Chiara; Falchi, Angela M.; Lippolis, Vito; Andrea Lorenzon; Macor, Paolo; Meli, Valeria; Monduzzi, Maura; Obiols-Rabasa, Marc; Petrizza, Luca; Luca Prodi; Rosa, Antonella; Schmidt, Judith; Talmon, Yeshayahu; Murgia, Sergio

 Customer publications

Cubosomes for in vivo fluorescence lifetime imaging

Biffi, Stefania; Andolfi, Laura; Caltagirone, Claudia; Garrovo, Chiara; Falchi, Angela M.; Lippolis, Vito; Andrea Lorenzon; Macor, Paolo; Meli, Valeria; Monduzzi, Maura; Obiols-Rabasa, Marc; Petrizza, Luca; Luca Prodi; Rosa, Antonella; Schmidt, Judith; Talmon, Yeshayahu; Murgia, Sergio

Herein we provided the first proof of principle for in vivo fluorescence optical imaging application using monoolein-based cubosomes in a healthy mouse animal model. This formulation, administered at a non-cytotoxic concentration, was capable of providing both exogenous contrast for NIR fluorescence imaging with very high efficiency and chemospecific information upon…
Characterization of Lipid-Based Hexosomes as Versatile Vaccine Carriers

Rodrigues, Letícia; Kyriakos, Konstantinos; Schneider, Fabian; Dietz, Hendrik; Winter, Gerhard; Papadakis, Christine M.; Hubert, Madlen

 Customer publications

Characterization of Lipid-Based Hexosomes as Versatile Vaccine Carriers

Rodrigues, Letícia; Kyriakos, Konstantinos; Schneider, Fabian; Dietz, Hendrik; Winter, Gerhard; Papadakis, Christine M.; Hubert, Madlen

Subunit vaccines typically show insufficient immunogenicity. To address this issue, we developed a novel self-adjuvanting particulate carrier system based upon the lipids phytantriol (Phy) and mannide monooleate (MaMo). Phy is a lipid known to form nonlamellar phases in fully hydrated systems, whereas MaMo has been found to promote immune responses…
Kinetic influence of siliceous reactions on structure formation of mesoporous silica formed via the co-structure directing agent route

Lin, Ruiyu; Carlström, Göran; Dat Pham, Quoc; Anderson, Michael W.; Topgaard, Daniel; Edler, Karen J.; Alfredsson, Viveka

 Customer publications

Kinetic influence of siliceous reactions on structure formation of mesoporous silica formed via the co-structure directing agent route

Lin, Ruiyu; Carlström, Göran; Dat Pham, Quoc; Anderson, Michael W.; Topgaard, Daniel; Edler, Karen J.; Alfredsson, Viveka

Journal of Physical Chemistry C, 2016, vol 120, 7, pp. 3814–3821DOI:Visit the full articleBack to the overview
Relationship between Side-Chain Polarity and the Self-Assembly Characteristics of Perylene Diimide Derivatives in Aqueous Solution

Schill, Jurgen; Milroy, Lech-Gustav; Lugger, Jody A. M.; Schenning, Albertus P. H. J.; Brunsveld, Luc

 Customer publications

Relationship between Side-Chain Polarity and the Self-Assembly Characteristics of Perylene Diimide Derivatives in Aqueous Solution

Schill, Jurgen; Milroy, Lech-Gustav; Lugger, Jody A. M.; Schenning, Albertus P. H. J.; Brunsveld, Luc

Perylene-3,4,9,10-tetracarboxylic acid diimides (PDIs) have recently gained considerable interest for water-based biosensing applications. PDIs have been studied intensively in the bulk state, but their physical properties in aqueous solution in interplay with side-chain polarity are, however, poorly understood. Therefore, three perylene diimide based derivatives were synthesized to study the…
Twist-bend nematics, liquid crystal dimers, structure–property relations

Dawood, Alya A.; Grossel, Martin C.; Luckhurst, Geoffrey R.; Richardson, Robert M.; Timimi, Bakir A.; Wells, Neil J.; Yousif, Yousif Z.

 Customer publications

Twist-bend nematics, liquid crystal dimers, structure–property relations

Dawood, Alya A.; Grossel, Martin C.; Luckhurst, Geoffrey R.; Richardson, Robert M.; Timimi, Bakir A.; Wells, Neil J.; Yousif, Yousif Z.

One of the current challenges in liquid crystal science is to understand the molecular factors leading to the formation of the intriguing twist-bend nematic phase (NTB) and determine its properties. During our earlier hunt for the NTB phase created on cooling directly from the isotropic phase and not the nematic…
Nanocomposites based on nanostructured PI-b-PMMA copolymer and selectively placed PMMA-modified magnetic nanoparticles: Morphological and magnetic characterization

Barandiaran, I.; Grana, E.; Katsigiannopoulos, D.; Avgeropoulos, A.; Kortaberria, G.

 Customer publications

Nanocomposites based on nanostructured PI-b-PMMA copolymer and selectively placed PMMA-modified magnetic nanoparticles: Morphological and magnetic characterization

Barandiaran, I.; Grana, E.; Katsigiannopoulos, D.; Avgeropoulos, A.; Kortaberria, G.

European Polymer Journal, 2016, vol 75pp. 514–524DOI:Visit the full articleBack to the overview
Concentration-Induced Association in a Protein System Caused by a Highly Directional Patch Attraction

Li, Weimin; Persson, Björn A.; Lund, Mikael; Bergenholtz, Johan; Zackrisson Oskolkova, Malin

 Customer publications

Concentration-Induced Association in a Protein System Caused by a Highly Directional Patch Attraction

Li, Weimin; Persson, Björn A.; Lund, Mikael; Bergenholtz, Johan; Zackrisson Oskolkova, Malin

Self-association of the protein lactoferrin is studied in solution using small-angle X-ray scattering techniques. Effective static structure factors have been shown to exhibit either a monotonic or a nonmonotonic dependence on protein concentration in the small wavevector limit, depending on salt concentration. The behavior correlates with a nonmonotonic dependence of…
Effects of chain configuration on the crystallization behavior of polypropylene based copolymers

Wamuo, Onyenkachi; Wu, Ying; Hsu, Shaw Ling; Paul, Charles W.; Eodice, Andrea; Huang, Kuan-Yeh; Chen, Meng-Hsin; Chang, Yih-Her; Lin, Jen-Lien

 Customer publications

Effects of chain configuration on the crystallization behavior of polypropylene based copolymers

Wamuo, Onyenkachi; Wu, Ying; Hsu, Shaw Ling; Paul, Charles W.; Eodice, Andrea; Huang, Kuan-Yeh; Chen, Meng-Hsin; Chang, Yih-Her; Lin, Jen-Lien

The effects of sequence distribution of two types of poly(propylene-ethylene) (PP-PE) copolymers, with propylene being the dominant component, on the associated crystallization behavior have been analyzed. The average sequence lengths of the crystallizable propylene sequences in these copolymers are different, although the ethylene content was virtually identical. In one case…
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