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Studying Excipient Modulated Physical Stability and Viscosity of Monoclonal Antibody Formulations Using Small-Angle Scattering

Xu, Amy Yuanyuan; Castellanos, Maria Monica; Mattison, Kevin; Krueger, Susan; Curtis, Joseph E.

ApplicationCharacterizationCustomer publicationsMaterialParticle interactionsProteins & DNA/RNASAXSStructural biologyTechnique

Studying Excipient Modulated Physical Stability and Viscosity of Monoclonal Antibody Formulations Using Small-Angle Scattering

Xu, Amy Yuanyuan; Castellanos, Maria Monica; Mattison, Kevin; Krueger, Susan; Curtis, Joseph E.

Excipients are substances that are added to therapeutic products to improve stability, bioavailability, and manufacturability. Undesirable protein-protein interactions (PPI) can lead to self-association and/or high solution viscosity in concentrated protein formulations that are typically greater than 50 mg/mL. Therefore, understanding the effects of excipients on nonspecific PPI is important for…
Tuning Pore Dimensions of Mesoporous Inorganic Films by Homopolymer Swelling

Reid, Barry; Alvarez-Fernandez, Alberto; Schmidt-Hansberg, Benjamin; Guldin, Stefan

ApplicationCharacteristic dimensionCharacterizationCustomer publicationsGISAXSInorganic materialMaterialOrientation analysisPhase analysisRenewable energySAXSSurface structure and patternsTechniqueThin films

Tuning Pore Dimensions of Mesoporous Inorganic Films by Homopolymer Swelling

Reid, Barry; Alvarez-Fernandez, Alberto; Schmidt-Hansberg, Benjamin; Guldin, Stefan

The functionality and applications of mesoporous inorganic films are closely linked to their mesopore dimensions. For material architectures derived from a block copolymer (BCP) micelle coassembly, the pore size is typically manipulated by changing the molecular weight corresponding to the pore-forming block. However, bespoke BCP synthesis is often a costly…
Tandem catalysis in multicomponent solvent-free biofluids

Atkins, Dylan Luke; Berrocal, José Augusto; Mason, Alexander Francesco; Voets, Ilja Karina

ApplicationCharacterizationCustomer publicationsMaterialProteins & DNA/RNASAXSShapeSizeStructural biologyTechnique

Tandem catalysis in multicomponent solvent-free biofluids

Atkins, Dylan Luke; Berrocal, José Augusto; Mason, Alexander Francesco; Voets, Ilja Karina

Enzymes are widely employed to reduce the environmental impact of chemical industries as biocatalysts improve productivity and offer high selectively under mild reaction conditions in a diverse range of chemical transformations. The poor stability of biomacromolecules under reaction conditions is often a critical bottleneck to their application. Protein engineering or…
A Cross-Method Comparison of Sub-10 nm Nanoparticle Size Distribution

Yang, Ye; Liao, Suiyang; Luo, Zhi; Qi, Runzhang; Mac Fhionnlaoich, Niamh; Stellacci, Francesco; Guldin, Stefan

ApplicationCharacterizationCustomer publicationsMaterialNanoparticles & colloidsParticle size and size distributionParticlesSAXSTechnique

A Cross-Method Comparison of Sub-10 nm Nanoparticle Size Distribution

Yang, Ye; Liao, Suiyang; Luo, Zhi; Qi, Runzhang; Mac Fhionnlaoich, Niamh; Stellacci, Francesco; Guldin, Stefan

Accurate nanoparticle (NP) size determination is essential across research domains, with many functions in nanoscience and biomedical research being size-dependent. Although transmission electron microscopy (TEM) is capable of resolving a single NP down to the sub-nm scale, the reliable representation of entire populations is plagued by challenges in providing statistical…
Fragmentation of 1,2-Polybutadiene-block-Poly(ethylene oxide) Micelles in Imidazolium-Based Ionic Liquids

Early, Julia T.; Lodge, Timothy P.

(Natural) polymersApplicationCharacteristic dimensionCharacterizationCustomer publicationsMaterialPolymer researchSAXSSelf-assembled materialTechnique

Fragmentation of 1,2-Polybutadiene-block-Poly(ethylene oxide) Micelles in Imidazolium-Based Ionic Liquids

Early, Julia T.; Lodge, Timothy P.

The effect of solvent selectivity on the fragmentation kinetics of spherical micelles formed by a 1,2-polybutadiene-block-poly(ethylene oxide) “BO” copolymer in five 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide-based ionic liquids (ILs), (, where n = methyl, ethyl, butyl, hexyl, and octyl) was investigated by temperature-jump dynamic light scattering (T-jump DLS),…
Reproducible Preparation of Proteopolymersomes via Sequential Polymer Film Hydration and Membrane Protein Reconstitution

Loo, Siew-Leng; Siti, Winna; Thiyagarajan, Monisha; Torres, Jaume; Wang, Rong; Hu, Xiao

(Natural) polymersApplicationCharacteristic dimensionCharacterizationCustomer publicationsMaterialProteins & DNA/RNASAXSStructural biologyTechnique

Reproducible Preparation of Proteopolymersomes via Sequential Polymer Film Hydration and Membrane Protein Reconstitution

Loo, Siew-Leng; Siti, Winna; Thiyagarajan, Monisha; Torres, Jaume; Wang, Rong; Hu, Xiao

Film rehydration method is commonly used for membrane protein (MP) reconstitution into block copolymer (BCP), but the lack of control in the rehydration step formed a heterogeneous population of proteopolymersomes that interferes with the characterization and performance of devices incorporating them. To improve the self-assembly of polymersomes with simultaneous MP…
Nanofibril Organization in Silk Fiber as Inspiration for Ductile and Damage-Tolerant Fiber Design

Lin, Shihui; Ye, Chao; Zhang, Wenwen; Xu, Anchang; Chen, Shixian; Ren, Jing; Ling, Shengjie

ApplicationCharacterizationCustomer publicationsFibersMaterialOrientation analysisOtherSAXSTechnique

Nanofibril Organization in Silk Fiber as Inspiration for Ductile and Damage-Tolerant Fiber Design

Lin, Shihui; Ye, Chao; Zhang, Wenwen; Xu, Anchang; Chen, Shixian; Ren, Jing; Ling, Shengjie

Ductile and damage-tolerant fibers (DDTFs) are desired in aerospace engineering, mechanical engineering, and biomedical engineering because of their ability to prevent the catastrophic sudden structural/mechanical failure. However, in practice, design and fabrication of DDTFs remain a major challenge due to finite fiber size and limited processing techniques. In this regard,…
Tubular Sensor with Multi-Axial Strain Sensibility and Heating Capability Based on Bio-Mimic Helical Networks

Li, Yijun; Zhang, Kailin; Nie, Min; Wang, Qi

(Natural) polymersApplicationCharacterizationCustomer publicationsFibersMaterialOrientation analysisPolymer researchSAXSTechnique

Tubular Sensor with Multi-Axial Strain Sensibility and Heating Capability Based on Bio-Mimic Helical Networks

Li, Yijun; Zhang, Kailin; Nie, Min; Wang, Qi

Sensors are crucial in industrial robotics and smart production line owing to the basic needs for human–machine communication and real-time monitoring. However, a lack of versatile sensing capability and multifunctionalities are still two urgent bottlenecks for current sensors to break through. In this study, from the biomimic perspective, helical and…