CAPZA Growth Tech makes investment in Xenocs, a worldwide technological leader in nanoscale material analysis

Press release – Paris, May 25^t^h, 2021

CAPZA, an independent management company and leading player in private investments in European SMEs – invests in Xenocs, a French deep tech company, through its new Growth Tech strategy.

Founded in 2000, Xenocs is a spin-off from the Institut Laue-Langevin (ILL). The company operates on the nanoscale material characterization market through the development and production of SAXS – Small-Angle X-Ray Scattering – instruments and software. It has made important technological advances in X-ray optics, as well as in data collection, processing and analysis software. This progress allows many industrial sectors to better optimize R&D, fabrication processes and control product quality. For example, by analyzing structure at the nanoscale, SAXS instruments help pharma giants characterizing proteins and developing new drugs.

Headquartered in Grenoble (France), Xenocs operates internationally through 4 subsidiaries based in the US, China, Singapore, Denmark and through an extensive network of agents in 12 countries. With a turnover of €16 million in 2020, Xenocs achieved a strong and profitable 25% annual growth in the last five years. The company currently employs 72 employees.

From left to right: Frédéric Bossan and Peter Høghøj from Xenocs, Jean-Luc CYROT and Raphael Horreard from Capza Growth Tech during closing of the investment agreement.

Owned and led by its founders Peter Høghøj and Frédéric Bossan, Xenocs is recognized as the most expert and innovative player in SAXS. Its products are considered having the highest level of performance, which gives the company a strong competitive advantage in terms of brand recognition and a sustainable base of customers, thus ensuring recurring revenues.

With CAPZA’s support, Xenocs’ ambition is:

to accelerate its commercial development;
to create new data processing and analysis software products to enlarge market accessibility;
and to enrich its current offer by potentially acquiring companies with adjacent and complementary technologies.

“We are delighted to support Xenocs in this new phase of its development alongside its founders to build a worldwide leader in nanoscale material characterization. Led by a competent and highly involved international management team, the Group shows great potential thanks to its strategic and technological position in SAXS market” – Jean-Luc Cyrot, Partner, CAPZA Growth Tech

“The entry of CAPZA Growth Tech in our capital is a steppingstone for the implementation of our ambitious growth strategy. Our goal is to position Xenocs as the leading supplier of the SAXS market” – Frédéric Bossan, Managing Director of Xenocs

“We are very much looking forward to working with the CAPZA Growth Tech team as we continue our journey. Their expertise and support will be crucial regarding the development of Xenocs, on both the organic and external growth sides.” – Peter Høghøj, CEO of Xenocs

CAPZA enters the capital of the Group as a minority shareholder, while Xenocs’ founders will maintain a majority share.
This will be a new transaction of CAPZA Growth Tech⁵ which is currently under fundraising.

Press contacts

Kristell Le Nadan – Citigate Dewe Rogerson
[email protected]
Tel: +33 (0)1 53 32 84 71 / +33 (0)6 98 49 22 27

Léa Schultz – Citigate Dewe Rogerson
[email protected]
Tel: +33 (0)7 57 52 06 05

About CAPZA Growth Tech

CAPZA Growth Tech is dedicated to high-growth profitable companies in the tech sector whose business model is focused on value creation. It relies on an experienced investment team, with complementary backgrounds in the tech sector (consulting, entrepreneurship, investment, management …) able to provide strategic and operational support to structure a profitable and sustainable growth.

About CAPZA

Created in 2004, CAPZA¹ is an established European private investment platform focused on small and mid-cap companies. The company is majority owned by its teams and supported by the AXA Group.

With €5.2bn of assets², CAPZA places its experience and passion for developing businesses at the service of investors in Europe and worldwide with its platform of 6 complementary areas of expertise: Flex Equity, Private Debt, Transition³, Artemid⁴, Growth Tech and Mid-Cap Expansion.

CAPZA offers financing solutions to small and mid-cap companies at every stage of their development. Its unique platform allows CAPZA to support companies over the long term by providing them with custom made financing solutions (majority equity, minority equity, subordinated debt, senior debt, etc.). CAPZA is a generalist but has built up strong expertise in supporting companies in the health, technology and services sectors.

CAPZA Group has more than 80 employees based in Paris, Munich, Madrid and Milan.

More information: https://capza.co Twitter: @capza_co

¹CAPZA (formerly Capzanine) is the commercial name of Atalante SAS, portfolio management company approved on 11/29/2014 by the « Autorité des Marchés Financiers » under GP-04000065.

²including assets managed by a third party and advised by Artemid SAS. Based on valuations as of 31/12/20 and also including funds raised until March 2021.

³ The funds of the CAPZA Transition range are managed by the asset management company CAPZA, and advised by CAPZA Transition SAS which has financial investment advisor status (CIF in France), is registered under the Orias under the number 18001601 since the 23/03/2018.

⁴ The funds of the Artemid range are managed by both by a third party and by the asset management company CAPZA and advised by Artemid SAS, which is a subsidiary of CAPZA and Amiral Gestion and has financial investment advisor status (CIF in France). Artemid SAS is registered by the Orias under the number 14003497 since the 05/28/2014.



Source	Microfocus sealed tube: Cu, 30W/30µm, point focus. ( DIN EN 12543-5) Polychromatic Copper microfocus source for imaging a field of view of 14 mm x 14 mm. MetalJet D2+ 70 kV source (Ga). Motorized Dual or Triple source (Cu/Mo/Cr/Ga).
Optics	Patented 3D single reflection multilayer optics.
Detector	In-vacuum motorized 3-axis detectors for 2D SAXS/WAXS (Q-Xoom): --Eiger2 R (500K, 1M or 4M) hybrid photon counting detectors Optional WAXS detectors for SWAXS: --Motorized 3-axis Eiger2 R 500K hybrid photon counting detector
Sample chamber	Large vacuum chamber. On-axis sample viewing (parallax free). Attachments for operation of sample in air. XL station: Dedicated air-space tailored for accommodating extra-large sample environments
Key features	Clean Beam technology: High flux and low background beamline. Beamstopless measurement: SAXS acquisition continuously without any beamstop. Q-Xoom: Automatic change of measurement configuration over all instrument Q-range with no movement of sample measuring position and automatic callibations. Virtual detector mode: Surfaces of detection > 200 mm x 200 mm.
Measurement capability	Nanoparticles size up to 250 nm, 500 nm or 900 nm in diameter depending on the Xeuss model. Nanoparticles size up to > 2.5 microns with optional motorized Bonse-Hart module for automatic sequential USAXS/SAXS/WAXS measurements. Nanoparticles sizes down to 50 nm can be measured using the AuX source on spot sizes of 150 microns and with measuring times in the range of a minute or less. Scattering measurements up to 2Ɵ > 70° with Q-Xoom. Qmax > 49 nm-1 The X-ray imaging option extends the range of structural information from Å to mm while the Dark-field and Phase-contrast imaging (DF-PCI) option reveals nanostructure differences, interfaces and orientation.
Sample environment	Standard holders (multi-samples): solids, capillaries, powders and gels. Flowcells for liquids: --- Low noise flowcell --- Capillary flowcell --- Automatic Sample Changer --- BioCube measuring cell with dynamic monitoring (compatible with pipetting robot) Temperature stages: --- Multi-purpose X-Ray temperature stage (-30°C to 150°C) --- High temperature sample stage (-150°C to 350°C) --- Extended high-temperature sample stage (ambient to 1000°C) Mechanical stress stages: --- Tensile Stage (0 N to 600N). --- Couette stage for shear SAXS. --- Cryo-Shear Cell (-50°C to +450°C). Humidity stage (5% to 95% humidity at temperatures ranging from 10°C to 70°C). Temperature compatible advanced GISAXS stage with incidence angle control and additional rotation for texture or in-plane scattering analysis Other sample stages available under request
Software	Comprehensive Software Suite: Xplore: command and control software for intuitive data acquisition with automatic data reduction in absolute units and live data display providing also real-time equipment monitoring and scripting capabilities from any programming language. XSACT Pro (X-ray Scattering Analysis and Calculation Tool) for data analysis and interpretation including unique modules for particle shape determination through direct modeling or AI-powered classification.
General parameters	Models & Footprint: Xeuss Pro C (1 m x 3.5 m), HR (1 m x 5 m), UHR (1 m x 8 m). Maximum power consumption: 4.8kW (single phase power)


Mirror type	Figure	Optic efficiency (calculated over mirror length for 70µm source)
Standard Montel mirrors		Eff = 42%
Xenocs FOX 3D mirrors		Eff = 62%


Model	Beam size at focus (mm) with 60 µm source	Divergence (mrad)	Typical application
FOX 3D Cu 14-39 (♦)	0.19 x 0.19	5.4	Protein crystallography (♦) Powder diffraction
FOX 3D Cu 12-53	0.3 x 0.3	3	Protein crystallography (Long Unit Cells) Powder diffraction
FOX 3D Mo 10-31	0.13 x 0.13	4	Small molecule crystallography High pressure diffraction
FOX 3D Ag 10-30	0.13 x 0.13	3	Small molecule crystallography High pressure diffraction
FOX 3D Cr 8-30	0.20 x 0.20	6	Protein crystallography (S-SAD) Stress analysis
FOX 1D Cu 12-53	0.3	3	XRD, Powder Diffraction


Model	Beam size at focus (mm) with 60 µm source	Divergence (mrad)	Typical application
FOX 2D Mo 25-25 (♦)	0.08 x 0.08	5	Small mollecule crystallography High pressure crystallography
FOX 2D Cu 25-25 (♦)	0.08 x 0.08	5.3	Protein crystallography (♦) Micro Diffraction, Reflectometry
FOX 3D Cu 21-21 HC (♦)	0.08 x 0.08	70 x 35	Rapid x-ray Reflectometry (full beam) Scanning x-ray Reflectometry (with slit) Micro-XRF
FOX 3D Cu 28-10	0.04 x 0.04	17	Stress Analysis, Micro-diffraction, Micro-XRF
FOX 3D Cr 30-8	0.04 x 0.04	17	Stress Analysis, Micro-diffraction, Micro-XRF


Model	Beam size at focus (mm) with 60 µm source	Divergence (mrad)	Typical application
FOX 2D Cu 12-INF (♦)	1.2 x 1.2	1	Small angle x-ray scattering (♦) High resolution x-ray diffraction (♦) Surface scattering (♦) Thin film analysis (reflectometry stress) (♦) Microdiffraction on synchrotron (♦)
FOX 2D Mo 25-INF (♦)	0.85 x 1.3	0.5	Small angle x-ray scattering High resolution x-ray diffraction Surface scattering
FOX 2D 12-60 L (♦)	0.18 x 0.2	0.5 x 2	High resolution diffraction Small sample analysis
FOX 1D Cu 12-INF (♦)	1.2	0.8	High resolution x-ray diffraction, Powder diffraction, Reflectometry, Small angle x-ray scattering


Model	Beam size at focus (µm)	Divergence (mrad)	Flux (ph/sec)	Typical application
GeniX 3D Cu High Flux *	< 190	6	> 400 x 10⁶	Protein crystallography Micro stress analysis Powder diffraction
GeniX 3D Mo High Flux	< 130	5	> 25 x 10⁶	Small Molecule crystallography High pressure
GeniX 3D Cr High Flux	< 190	6	> 300 x 10⁶	Stress Analysis
GeniX 3D Cu High Convergence *	60	70 x 35	> 400 x 10⁶	Rapid X-ray Reflectometry (full beam) Scanning x-ray reflectometry (with slit) Micro x-ray fluorescence Small spot diffraction on thin film
GeniX 3D Cu Low Convergence *	< 250	3	> 120 x 10⁶	Small Angle X-ray Scattering Protein Crystallography


Model	Detailed specifications
Synchrotron scatterless slits (♦)	Please contact us for any technical information Discover what our customers say about it!
X-ray alignment camera (♦)	Please contact us for any technical information
Pin Diode detector (♦)	Please contact us for any technical information
Beam stop with integrated Pin Diode	Please contact us for any technical information


BioXolver configurations	BioXolver	BioXolver L
Utilisation	Research on biological macro-molecules in solution	Research on biological macro-molecules, including large complexes and interactions
X-ray source	Microfocus GeniX 3D, MetalJet, add-on to RAG	0.02-0.3nm
Optic	Aspheric single reflection multilayer optic
Collimation	Motorized scatterless point collimation	variable
Sample cell	Xenocs thermalized BioCube flow-cell with camera and pump
Sample handling	Pipetting robot with disposable tips
Sample capacity	Up to 2 x 96 well plates (thermalized)
Minimum sample volume	Down to 5 μL
Cleaning	Automated cleaning and drying with three cleaning fluids
Detector	Dectris in-vacuum hybrid pixel photon counting detector
Detector configuration	Fixed detector distance	Variable detector distance
Data reduction and analysis software	RAW and ATSAS
Q-range and typical protein size*	0.006 Å-1 / MW < 200 MDa / Rg < 135 Å	0.003 Å-1 / MW < 1.5 GDa / Rg < 270 Å
Overall length	3.2 m (2.7 m as add-on to existing source)	4.2 m
Options	UV-Vis, separate temperature control for sample trays and BioCube	UV-Vis, separate temperature control for sample trays and BioCube
Services	Installation, training, hot-line, maintenance contract	Installation, training, hot-line, maintenance contract



Source and optics	Microfocus sealed tube: Cu, 30W/30µm, point focus. ( DIN EN 12543-5) Patented 2D single reflection multilayer optics.
Detector	Dectris Pilatus 3 hybrid photon counting detectors. Two fixed detectors for continuously and simultaneously. SAXS and WAXS acquisition up to 2θ=60°.
Beam Path	Windowless beam path entirely under vacuum from beam delivery system to detector sensor
Key features	Clean Beam technology: high flux and low background beamline. Beamstopless measurement: SAXS acquisition continuously without any beamstop. Virtual detector mode: > 200° azimuth coverage with rotation of sample.
Measurement capability	Nanoparticles size up to 250 nm in diameter.
Sample environment	Standard holders: solids, capillaries, powders. Sample holders for powders and gels. Flow cells for liquids: --- Low noise flow cell --- Capillary flow cell Automatic Sample Changer Temperature stages: --- Multi-purpose X-Ray Temperature Stage (-20°C to 150°C) --- High temperature sample stage (-150°C to 350°C) --- Extended high temperature sample stage (amb - 700°C) Tensile Stage (0-200N). GiSAXS stage compatible with high temperature sample stage. Custom stages on request.
Software	Acquisition software with automatic data reduction in absolute units and live data display. XSACT (X-ray Scattering Analysis and Calculation Tool) for data analysis and interpretation.
General parameters	Fooprint: < 1x1 m². Weight: ~ 520 kg. Maximum power consumption: < 2000 W (single phase power). Self-contained: no external fluids required.
Warranty	Two years warranty and three years on X ray source.


Element of interest	Reference
O, F, Na, Mg, Al, Si, P, S	XAN-1
Nitrogen	XAN-2
Carbon	XAN-3
Boron	XAN-4
Mg, Al , Si	XAN-5
Be	XAN-6

CAPZA Growth Tech makes investment in Xenocs, a worldwide technological leader in nanoscale material analysis

CAPZA, an independent management company and leading player in private investments in European SMEs – invests in Xenocs, a French deep tech company, through its new Growth Tech strategy.

From left to right: Frédéric Bossan and Peter Høghøj from Xenocs, Jean-Luc CYROT and Raphael Horreard from Capza Growth Tech during closing of the investment agreement.

Press contacts

About CAPZA Growth Tech

About CAPZA

1 CAPZA (formerly Capzanine) is the commercial name of Atalante SAS, portfolio management company approved on 11/29/2014 by the « Autorité des Marchés Financiers » under GP-04000065.

2 including assets managed by a third party and advised by Artemid SAS. Based on valuations as of 31/12/20 and also including funds raised until March 2021.

3 The funds of the CAPZA Transition range are managed by the asset management company CAPZA, and advised by CAPZA Transition SAS which has financial investment advisor status (CIF in France), is registered under the Orias under the number 18001601 since the 23/03/2018.

5 Via Warehousing

Useful links

X-ray Optics

Xenocs proposes a wide range of optics for both XRD and XRF applications.

2D-3D Beam shaping X-ray Optics

High Flux Optics

Small Spot Optics

Collimating Optics

1D Beam shaping X-ray Optics

High Flux Optics

Collimating Optics

X-ray beam delivery system

The combination of an innovative design and the FOX3D single reflection optics makes the GeniX3D a unique solution on the market.

High flux solutions

Small spot solutions

X-ray beam accessories

In addition to our high quality optical components and beam delivery systems, we propose accessories to optimize the performance of your setup.

Xeuss 3.0 specifications

Plenty of space for sample environment

With its large chamber and concept ensuring stationary sample during measurement, the Xeuss 3.0 is the perfect X-ray scattering platform instrument for now and the future.

Ultimate performance

The Xeuss 3.0 offers a maximum flexibility of measurement configurations to get the best possible data quality on any type of sample.

Xeuss 3.0 shown with Q-Xoom transparency to illustrate the moving detector.

Maximum flexibility

Provide structural tools to a large community of users with full remote operation capability and access to a unique range of length-scales.

Q-Xoom – enjoy the flexibility of full-range computer-controlled detector travel

Measure probe lengths as large as 4.5 microns together with nanoscale information

Optimize your experiment to any type of sample (absorption, fluorescence, characteristic dimensions)

Simultaneously from atomic to nanoscale

No need to repeat SAXS and WAXS measurement, you get two measurements within one exposure.

Extensive and powerful suite of data analysis algorithms

XSACT includes an extensive array of analysis modules for sample characterization of size, structure and texture of multiple types of materials including nanoparticles and polymers.

Low cost of ownership

Get nanoscale information on a day to day basis to improve your material process or validate your research models.

Accurate and high dynamic range measurement

Focus your attention on science and data interpretation, you can rely on your data.

Publication quality figure presentation

XSACT is a time saver as it bundles all the tools to create publication-ready figures without the need for another visualization software.

High quality SAXS data in the lab

Measurements previously only possible at synchrotron facilities can now be done in the lab.

High throughput measurements and results

Full automation from sample to final results on up to 192 samples.

In-line SEC and UV-Vis combined with SAXS – also in the lab!

Obtain the structure of small and large protein species through in-line gel filtration

BioXolver specifications

*Theoretical limit assuming globular proteins

智能工作流程和用户体验

使用XSACT可使用户用最小投入获得数据解析结果。

样品 – 测试 – 分析 – 报告 – 节约时间

智能工作流程和用户体验

使用XSACT可使用户用最小投入获得数据解析结果。

样品 – 测试 – 分析 – 报告 – 节约时间

在实验室中得到高质量SAXS数据

以前的测试只能在同步辐射完成，现在也可在实验室中实现。

SAXS可以和在线SEC、UV-Vis联用 – 在实验室也可以实现!

通过内置胶体过滤获取不同尺寸蛋白质种类的结构

低样品消耗量

低至5μL。目前是市场上最低的样品消耗量。

内容广泛、性能强大的数据分析算法软件

XSACT包括一系列的广泛的分析模块，用于对多种类型的材料包括纳米颗粒和聚合物的尺寸、结构和织构进行样品表征等。

同时从原子级别到纳米尺寸

无需重复SAXS和WAXS测试，您可以在一次曝光内同时得到所有测量结果。

高精度高动态范围测量

获取可信赖的数据，将您的注意力集中在科学和数据解释上。

更高的灵活性

为广大用户群体提供全远程自动操作的、具备表征超大纳米尺度范围的独特工具。

Q-Xoom–享受全范围计算机控制探测器行程的灵活性

测量尺度可达4.5微米，并获取纳米尺度信息

对任何种类样品(吸收，荧光，特征尺寸)的实验进行优化

高性能

Xeuss 3.0实验装置具备最大的灵活性，用于测试各种样品并尽可能获取最佳质量的数据。

¹CAPZA (formerly Capzanine) is the commercial name of Atalante SAS, portfolio management company approved on 11/29/2014 by the « Autorité des Marchés Financiers » under GP-04000065.

²including assets managed by a third party and advised by Artemid SAS. Based on valuations as of 31/12/20 and also including funds raised until March 2021.

³ The funds of the CAPZA Transition range are managed by the asset management company CAPZA, and advised by CAPZA Transition SAS which has financial investment advisor status (CIF in France), is registered under the Orias under the number 18001601 since the 23/03/2018.

⁵ Via Warehousing