Improved screening capability with FOX 2D 25_25 optic at Princeton University

March 18, 2011

Phil Jeffrey
Crystallography Facility Manager in the department of Molecular Biology at Princeton University

The department of Molecular Biology at Princeton University is operating a Rigaku RuH3R generator, with Copper anode and a 0.3x3mm cathode and a Rigaku Raxis IV++ area detector. This system is dedicated to macromolecular crystallography. One year ago, the department acquired a FOX 2D 25_25 optic in substitution of Yale Mirrors.

princeton-university "We use the system primarily for screening crystals prior to synchrotron trips but also for collecting native datasets from crystals that diffract better than average. Usage varies according to need.Previously we had mirrors of the Yale design installed on this system. The FOX 2D 25_25 was a replacement for this that fit into approximately the same footprint as the Yale mirrors, was of a design that took advantage of the larger focus spot on our generator. We have also found Xenocs professional and easy to work with.

When asked about the advantages of the FOX 2D 25_25 optic for its application, Phil Jeffrey reports ‘‘The FOX 2D 25_25 has a smaller native beam, greater intensity and flux, and much better spectral purity than the old Yale mirror design. Each feature leads to better data, or faster data collection, or both. Its physically compact design and ability to use more of the focal spot than multilayer optics designed for microfocus generators meant that we could make the most of our existing hardware. It is also easy to adjust and requires minimal maintenance.

Smaller beam size is a gain when working with the progressively smaller crystals that are of the norm. We also gained in brightness and the substantial reduction in CuKb contamination that was previously an issue in some circumstances. We would unhesitatingly recommend this optic for others in a similar situation to ours."

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