SAS2018

Michigan, USA
October 7-12, 2018


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Xenocs sponsors the XVII International Small Angle Scattering Conference (SAS2018) which will take place at Grand Traverse Resort & Spa, Traverse City, Michigan, from October 7 to 12, 2018.

We are delighted to welcome you on our booth and to the events we are organizing this week for SAS2018!

Scientific Lunchtime Session organized by Xenocs

“Frontier research using SAXS in the lab” 

Monday October 8,  12:50 - 13:50

Governor’s Hall CDEF

 

Synopsis: This scientific session will highlight examples on frontier research and development supported by laboratory based SAXS. It will cover small angle x-ray scattering applied to soft matter in general and surfactants in particular, in solid or diluted form, but also to low scattering systems such as biological compounds.

 

Co-chairs: Dr. Brian Pauw, BAM, Germany; Dr. Pierre Panine, Xenocs, France

 

Confirmed speakers:

  • Dr. Oleksandr O. Mykhaylyk

Affiliation: Soft Matter Analytical Laboratory, Department of Chemistry, The University of Sheffield, Sheffield, S3 7HF, UK

Title: "Applications of State-Of-The-Art Laboratory SAXS Instrument for Structural Characterization of Nanomaterials"

Abstract: Continuous improvement of synchrotron sources providing high brilliance X-ray radiation is shadowed by a simultaneous progress in development of laboratory X-ray scattering instruments which is driven by the fact that the laboratory instruments allow in-house research to be carried out with a relatively easy 24/7 access to these facilities. Recent innovations in key components of small-angle X-ray scattering (SAXS) instruments provided a new level of performance for the laboratory instruments comparable with 1st generation of synchrotrons. Applications of state-of-the-art Xeuss 2.0  SAXS/WAXS/GISAXS/GIWAXS instrument (Xenocs, France), equipped with a metal jet liquid Gallium X-ray source (Excillum, Sweden), for structural characterization of nanomaterials are presented. This includes routine static measurements on colloids and more advanced measurements on evolution of structural morphology in soft-matter materials such as time-resolved measurements of polymerization-induced self-assembly of copolymers during chemical reactions and thermally-induced morphological transformations of self-assembled block-copolymers, SWAXS measurements of flow-induced crystallisation of semi-crystalline polymers, SAXS analysis of oriented block-copolymer structures as well as GIWAXS of crystallization kinetics of photovoltaic materials.

 

  • Dr. Eric Robles

Affiliation: Research Fellow, Procter & Gamble, Newcastle Innovation Centre, United Kingdom

Title: "Innovation in Consumer Goods Driven by Mechanistic Insights via SAXS"

Abstract: Models that correlate product microstructure to performance is critical to develop innovative products that consumers would love to use at home. Understanding the structures found in such products span a wide time and length scales: from milliseconds to years and angströms to centimeters. In the FMCG industry, we employ various techniques that can cover such a wide range of time and length scales. Scattering techniques (light, neutron, x-ray) is one of the suites of tools used to probe the product microstructure. Depending on the time and length scales required, we either use large scale facilities (neutron, synchrotron x-ray) across the globe or lab-based systems (SLS, DLS, SAXS/WAXS, XRD, laser diffraction). This talk will highlight a few examples on how we fundamentally understand and optimise manufacturing/process transformations, product stability and product performance using various complimentary techniques, with particular emphasis to benchtop SAXS/WAXS.

Note: FMCG stands for Fast Moving Consumer Goods

  

  • Dr. Alexey Grishaev

Affiliation: NIST Biomolecular Measurement Division, Institute for Bioscience and Biotechnology Research, Rockville, MD, USA

Title: "Structure, conformational dynamics and hydration of RNA and DNA from wide-angle X-ray scattering, NMR, and computation"

Abstract: Determination of accurate structural models of RNA and DNA at native conditions remains incredibly challenging for both the experimental biophysical techniques such as X-ray crystallography, NMR, or cryo-EM, and the molecular simulation-based approaches. Small- and wide-angle x-ray scattering offers a very attractive way to characterize these systems but the majority of such studies concentrate on the lower-angle scattering and lower-resolution reconstructions, leaving out feature-rich wide angle scattering due to known difficulties in modeling these data from the atomic coordinates of oligonucleotides. In this study we investigate the reason for this structure/data discrepancy concentrating on a carefully selected set of RNA and DNA model systems characterized by NMR that represent state-of-the art of the technique’s applications. We find that even with the highest density of the experimental restraints and the best available force fields, leading to the most accurate NMR-determined RNA and DNA structures up to date, the resulting atomic coordinates nearly universally fail to quantitatively match the experimental wide-angle solution X-ray scattering data. We show that the effect most strongly contributing to this discrepancy is the single-conformation representation of these models. We thus propose a new methodology for simultaneously determining the average structure, conformational fluctuations, and the structure of the hydration layer of RNA and DNA from the joint analysis of NMR and wide angle solution scattering data, aiming to minimize data over-fitting and incorporating structural information from both high-level MD simulations in explicit solvent, and the conformational preferences extracted from the high-resolution subset of oligonucleotide structures in the PDB.

 

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